Toad Gallbladder is the name of a traditional Chinese medicinal material. It is the gallbladder of the Chinese giant toad (Bufo bufogargarizans Cantor) or the black-eyed toad (B. melanostictus Schneider) of the family Bufonidae. It has the effects of suppressing coughs, expelling phlegm, detoxifying, and dispersing nodules.It is primarily used to treat bronchitis, loss of voice in children, early-stage lymph node tuberculosis, and nasal furuncles.
Toad Gallbladder
Toad Gallbladder is the name of a traditional Chinese medicinal material. It is the gallbladder of the Chinese giant toad (Bufo bufogargarizans Cantor) or the black-eyed toad (B. melanostictus Schneider) of the family Bufonidae. It has the effects of suppressing coughs, expelling phlegm, detoxifying, and dispersing nodules.It is primarily used to treat bronchitis, loss of voice in children, early-stage lymph node tuberculosis, and nasal furuncles.
Chinese Name : 蟾蜍胆
Nature, Flavor & Meridian Tropism : Bitter in taste, cold in nature
Benefits & Efficacy
Benefits
Suppresses coughs, expels phlegm, detoxifies, and disperses nodules.
Indications
Bronchitis, pediatric loss of voice, early-stage lymph node tuberculosis, and nasal furuncles.
Usage and Dosage
Oral use: Dissolve 3–6 pieces in hot water. External use: Apply an appropriate amount after crushing into a paste; or apply fresh juice by dripping.
Precautions
Contraindicated for pregnant women.
Chemical Constituents
Toad bile contains higher bile acids and cholestanol.The major components of the higher bile acids include trihydroxy-bufostan-12-enoic acid, trihydroxy-isostan-12-enoic acid, △23-3α,7α,12α-trihydroxy-coprostan-12-enoic acid, and trihydroxy-bufostan-12-cholic acid.Bufalbin I is found in the bile of Japanese toads, along with bufalbin dihydroxycholanic acid; the bile sterols of Bufovulgaris formosus include tetrahydroxybufalan,5-hydroxybufuran, 4-hydroxycholane, and isotriohydroxybufene, among others.
Pharmacological Actions
Cardiotonic Effects: Toad bile exerts a cardiotonic effect on isolated hearts, increasing cardiac output and enhancing myocardial contractility, but it has an inhibitory effect on heart rate. The cardiotonic effect of bile exhibits a clear dose-response relationship within a certain range, and its mechanism of action may be related to calcium channels in myocardial cell membranes.
Relevant Discussions
1. *De Pei Ben Cao*: “Applying toad bile to the tongue treats loss of voice in children due to umbilical wind.”
2. *Common Medicinal Animals*: “Suppresses cough, expels phlegm, calms the lungs, and reduces inflammation. Primarily used to treat bronchitis.”
Applications
Related Compatibility
1. For bronchitis: 3 toad gallbladders. Dissolve in plain water and drink. Take twice daily for a continuous period. (*Jilin Herbal Medicine*)
2. For loss of voice and inability to speak in children: Apply fresh toad bile by dripping it onto the child’s uvula. (*Qingdao Manual of Herbal Medicine*)
3. For lung cancer: 7–10 toad gallbladders. Take orally in two divided doses; may be taken continuously for 1–2 months. (*Gansu Manual of Chinese Herbal Medicine*)
4. For early-stage lymph node tuberculosis: Apply the bile from several toad gallbladders to the affected area. (*Medicinal Animals of Guangxi*)
5. For nasal boils: 3 toad gallbladders, an appropriate amount of fresh Ren Zhong Bai, and 0.6 g of borneol. Pound all ingredients into a paste and apply to the affected area. (Jiangxi *Manual of Herbal Medicine*)
Processing & Preparation
Harvesting & Processing
Capture in summer or fall; perform a laparotomy to extract the gallbladder, wash it thoroughly, and use it fresh.
Crude Drug Identification
Botanical Information
Morphological Characteristics
1. Chinese Giant Toad: Body length generally exceeds 10 cm; robust build; head width greater than head length; rounded snout tip with a prominent snout ridge; nostrils near the tip of the snout; interorbital distance greater than the inter-nostril distance; eardrum clearly visible; no palatine teeth; upper and lower jaws are toothless.The forelimbs are long and stout; the fingers and toes are slightly flattened, with a faint marginal membrane on the sides of the fingers but no webbing; the finger lengths are, in order, 3, 1, 4, 2; the tubercles below the finger joints are mostly paired; there are two palmar protuberances, with the lateral one being larger.The hind limbs are stout and short; the tibio-tarsal joint extends forward to the shoulder level; the heels do not touch one another; the sides of the toes have marginal membranes, and the webbing is fairly well-developed; the medial metatarsal is elongated and large, while the lateral metatarsal is small and round.The skin is extremely rough; the top of the head is relatively smooth, with large, elongated parotid glands on both sides. The rest of the body is covered with round tubercles of varying sizes; those arranged in a relatively regular pattern are located behind the head, while those arranged diagonally run almost parallel to the parotid glands.In addition, the tubercles along the flanks are also arranged relatively regularly; those on the shins are larger; some specimens have indistinct tarsal folds; and the ventral skin is not smooth but covered with small tubercles.Color variation is considerable; during the breeding season, males are mostly blackish-green on the dorsal side, with pale markings on the flanks; females are paler on the dorsal side, with milky-yellow tubercles, and sometimes have oblique black longitudinal stripes extending from behind the eyes along the flanks; the ventral side is milky-yellow with fine brown or black patterns. Males are smaller and have black nuptial pads on the inner three toes, but lack vocal sacs.2. Black-eyed Toad: Body length 7–10 cm; males are slightly smaller. The head is high, and its width exceeds its length. The snout is rounded with a distinct snout ridge; the nostrils are near the tip of the snout. The interorbital distance is greater than the intranasal distance. The eardrum is large; there are no palatine teeth; both the upper and lower jaws are toothless; and the posterior end of the tongue lacks a notch.The head features very distinct black bony ridges or black lines along the snout ridge, the upper edge of the eye sockets, the anterior margin of the eardrum, and the margins of the upper and lower jaws. The top of the head is distinctly concave, and the skin is tightly attached to the skull. The forelimbs are slender and long; the fingers and toes are slightly flattened, with black tips; the digit order is 3, 1, 4, 2;subphalangeal tubercles are mostly paired; the lateral metacarpal tubercle is large, while the medial one is slightly smaller, both brown in color; the hind limbs are short, with the tarsometatarsal joint extending to the rear of the shoulder; the heels do not touch one another; the feet are shorter than the tibia; the sides of the toes are connected by a membrane forming a semi-web; subphalangeal tubercles are not prominent; the medial metatarsal tubercle is slightly larger than the lateral one.The skin is extremely rough; except for the top of the head, which is wart-free, the rest of the body is covered with round warts of varying sizes, some of which bear black spots or spines; the sides of the head feature oblong parotid glands; near the midline, from the back of the head to the hindquarters, there are two relatively regular rows of large warts arranged longitudinally.Large specimens of the Black-eyed Toad have their ventral surfaces covered with small spines. Body coloration varies considerably during their active period, generally appearing yellowish-brown with faint reddish-brown markings. Males possess black nuptial pads on the inner sides of the bases of the first and second digits, and a single subglottal vocal sac.
Distribution Area
1. Chinese Giant Toad: Found in Northeast China, North China, East China, Central China, as well as Shaanxi, Gansu, Qinghai, Sichuan, and Guizhou. 2. Black-eyed Toad: Found in Zhejiang, Jiangxi, Fujian, Taiwan, Hunan, Guangdong, Guangxi, Sichuan, Guizhou, and Yunnan.