Phellodendron, a name in traditional Chinese medicine. It is the dried bark of Phellodendron chinense Schneid., a plant in the genus Phellodendron of the Rutaceae family, commonly known as “Sichuan Phellodendron.” It has the effects of clearing heat and drying dampness, purging fire and eliminating steaming heat, and detoxifying and treating sores.It is primarily used to treat damp-heat-induced diarrhea and dysentery, jaundice with dark urine, vaginal discharge with genital itching, painful and scanty urination due to heat, beriberi with paralysis, bone-consuming fever, night sweats, nocturnal emission, sores, swellings, and toxic infections, as well as eczema and damp sores.
Phellodendron
Phellodendron, a name in traditional Chinese medicine. It is the dried bark of Phellodendron chinense Schneid., a plant in the genus Phellodendron of the Rutaceae family, commonly known as “Sichuan Phellodendron.” It has the effects of clearing heat and drying dampness, purging fire and eliminating steaming heat, and detoxifying and treating sores.It is primarily used to treat damp-heat-induced diarrhea and dysentery, jaundice with dark urine, vaginal discharge with genital itching, painful and scanty urination due to heat, beriberi with paralysis, bone-consuming fever, night sweats, nocturnal emission, sores, swellings, and toxic infections, as well as eczema and damp sores.
Chinese Name : 黄柏
Latin Name : Phellodendri Chinensis Cortex
Aliases : Phellodendron wood, Phellodendron bark, Huangbo
Authentic Producing Area : Sichuan, Guizhou
Nature, Flavor & Meridian Tropism : Bitter in taste, cold in nature; enters the Kidney and Bladder meridians
Benefits & Efficacy
Benefits
Clears heat and dries dampness; purges fire and eliminates night sweats; detoxifies and treats sores.
Indications
Dysentery caused by damp-heat, jaundice with red urine, vaginal discharge with genital itching, painful and scanty urination due to heat, beriberi with paralysis, bone-consumptive fever, night sweats, nocturnal emission, sores, swellings, and toxic abscesses, eczema, and damp sores.
Usage and Dosage
1. Internal use: Decocted, 3–12 g. 2. External use: As needed.
Precautions
This herb is bitter and cold in nature and may easily damage stomach qi; it is contraindicated for those with spleen-stomach deficiency-cold.
Chemical Constituents
Phellodendron primarily contains alkaloids such as berberine, phellodendrine, phellodendronine, magnolidine, and phellodendronine.
Pharmacological Actions
Phellodendron exhibits antimicrobial, anti-inflammatory, immunosuppressive, antihypertensive, antioxidant, and anti-gout effects, as well as the ability to improve energy metabolism.
Relevant Discussions
1. *Shennong’s Classic of Materia Medica*: “It treats heat accumulation in the five viscera and the stomach and intestines, jaundice, hemorrhoids, diarrhea, abnormal vaginal discharge (both red and white) in women, and erosive sores in the genital area.”
2. *Zhenzhu Nang*: “Phellodendron has six uses: first, to purge ‘dragon fire’ from the bladder; second, to promote urination in cases of urinary obstruction; third, to eliminate dampness and swelling in the lower jiao; fourth, to treat dysentery with initial blood in the stool; fifth, to relieve umbilical pain; and sixth, to tonify kidney deficiency and strengthen the bone marrow.”
Applications
Clinical Applications
1. To treat yellow, turbid, and foul-smelling leukorrhea caused by damp-heat descending to the lower jiao, it is commonly combined with Chinese yam (Shanyao), water caltrop (Qianshi), and plantain seed (Cheqianzi), as in the Yi Huang Decoction (*Fu Qingzhu’s Gynecology*); to treat damp-heat descending to the bladder, resulting in scanty, red, hot, and painful urination, it is commonly combined with Smilax glabra (Biqi), Poria (Fuling), and plantain seed (Cheqianzi), as in the Biqi Fenqing Decoction (*Insights into Medicine*).
2. For treating diarrhea and dysentery, it is commonly combined with herbs such as Whitehead (Baitouweng), Coptis (Huanglian), and Qinpi, as in the Whitehead Decoction (Shanghan Lun); when combined with Gardenia (Zhizi), it can treat jaundice caused by stagnant damp-heat, as in the Gardenia and Cypress Bark Decoction (Shanghan Lun).
3. To treat swelling, pain, and atrophy of the legs caused by damp-heat descending to the lower body, it is often combined with Atractylodes lancea and Achyranthes bidentata, as in the San Miao Pill (*Insights into Medicine*). When combined with Anemarrhena asphodeloides, prepared Rehmannia glutinosa, and turtle shell, it can treat atrophy caused by yin deficiency with excessive fire, as in the Hu Qian Pill (*Danxi’s Heart Method*).
4. To treat yin deficiency with excessive fire, characterized by tidal fever, night sweats, lower back soreness, and seminal emission, it is often used in synergy with Anemarrhena, along with Raw Rehmannia and Chinese Yam, as in the Anemarrhena-Phellodendron-Rehmannia Pill (from *The Golden Mirror of Medical Orthodoxy*); or combined with Prepared Rehmannia and Turtle Shell, as in the Great Yin-Nourishing Pill (from *Danxi’s Heart Method*).
5. For treating sores, abscesses, and toxic swellings, it can be used both internally and externally. For example, in Huanglian Jiedu Decoction (*Wai Tai Mi Yao*), this herb is combined with Scutellaria baicalensis, Coptis chinensis, and Gardenia jasminoides and taken as a decoction;or Er Huang San (from *Divine and Effective Secret Formulas for Boils and Abscesses*), which combines this herb with Rheum officinale into a powder, mixed with vinegar for topical application; to treat eczema and itching, it can be combined with Schizonepeta tenuifolia, Sophora flavescens, and Cortex Phellodendri to be decocted and taken orally; it can also be combined with calcined gypsum in equal parts to form a powder, which is sprinkled externally or mixed with oil and applied to the affected area, such as in Shi Huang San (from *Secret Transmission of the Blue Sack*).
Related Compatibility
1. Phellodendron combined with Pulsatilla: Phellodendron excels at purging kidney fire and clearing damp-heat in the lower jiao; Pulsatilla enters the Stomach and Large Intestine meridians, penetrates the blood to clear intestinal heat, and is highly effective at eliminating accumulated heat toxins in the stomach and intestines, making it a key herb for treating febrile dysentery. When these two herbs are used in combination, their ability to purge heat, dry dampness, clear the intestines, and detoxify is greatly enhanced. This formula is suitable for treating damp-heat dysentery.
2. Phellodendron combined with Asarum: Phellodendron specializes in purging kidney fire and clearing damp-heat in the lower jiao; Asarum is pungent, warm, and potent, dispersing head wind upward, unblocking kidney qi downward, and opening the orifices to relieve pain.When combined, these two herbs integrate cold and hot properties to complement each other. While Huang Bai moderates Xixin’s warming nature, Xixin still enters the Shaoyin channel to unblock kidney qi and open the orifices, facilitating the passage of fluid and assisting Huang Bai in purging “ministerial fire” and clearing damp-heat. This combination is suitable for conditions characterized by frequent and urgent urination with difficult urination and urinary tract pain.
3. Phellodendron combined with Cinnamon Bark: Phellodendron is bitter and cold; it clears ministerial fire, dries dampness, and consolidates yin. Cinnamon Bark is pungent, sweet, and extremely hot; it warms and tonifies kidney yang, strengthens fire, and dispels yin. These two herbs work synergistically to warm yang and transform qi without generating pathogenic heat, enabling yang to enter yin; they dry dampness and clear heat without causing cold stagnation, allowing yin to emerge from yang. This combination is suitable for conditions such as difficulty urinating and urinary retention caused by kidney yang deficiency, impaired qi transformation, and internal retention of damp-heat.
4. Phellodendron combined with Atractylodes: Phellodendron is bitter and cold, with a heavy aroma and taste; its nature is sinking and descending, excelling at clearing damp-heat in the Lower Jiao. Atractylodes has a pungent taste and a dispersing action; its nature is warm and drying. It transforms dampness and regulates the spleen, dispels wind and removes dampness, and treats both internal and external damp pathogens.When combined, Atractylodes’ ability to dry dampness is greatly enhanced by Phellodendron; conversely, Phellodendron, tempered by Atractylodes’ warmth, clears heat without damaging Yang. The two herbs complement and balance each other, acting in concert to descend to the lower jiao, resulting in a remarkable effect in clearing heat and drying dampness. This combination is indicated for heat-bi syndrome, swelling and pain in the tendons and bones due to descending damp-heat, weakness and flaccidity of the lower limbs, damp-heat leukorrhea, and eczema.
5. Phellodendron combined with Turtle Shell: Phellodendron is cold in nature, descending and moistening; it excels at purging ministerial fire and rescuing kidney water. Turtle Shell is cool in nature, with a thick and turbid quality; as a purely yin substance, it enters the Liver and Kidney meridians, tonifying the Liver and Kidney while nourishing yin and subduing fire.When used in combination, these two herbs complement each other: they nourish yin without retaining pathogens, clear and drain without damaging yin, and combine nourishment with descent and clearing with tonification. By addressing both the root and the symptoms, they jointly achieve the effect of nourishing yin and reducing fire. This combination is suitable for conditions such as bone-steaming fever, night sweats, seminal emission, soreness and weakness in the lower back and knees, and weakness of the tendons and bones resulting from deficiency of the liver and kidneys and yin deficiency with excessive fire.
Medicinal Identification
1. Raw Phellodendron, Salted Phellodendron, Wine-Processed Phellodendron, and Charred Phellodendron: Raw Phellodendron is bitter, drying, cold in nature, and sinking; it has a strong effect in purging fire, resolving toxins, and drying dampness. It is commonly used for damp-heat dysentery, jaundice, heat-induced dysuria, swelling and pain in the feet and knees, swollen and toxic sores, and eczema.Salt-processed Phellodendron has a milder bitter and drying nature; it is more effective at nourishing yin, reducing fire, and alleviating deficiency-heat. It is primarily used to treat yin deficiency fever, bone-consumptive fever with night sweats, nocturnal emissions, weakness and atrophy of the feet and knees, and coughing with hemoptysis.Wine-processed Phellodendron has a milder bitter and cold nature, which prevents damage to spleen yang. It utilizes the ascending properties of wine to direct the herb’s action upward, making it particularly effective at clearing heat in the upper jiao. It is used to treat conditions caused by heat stagnation in the upper jiao, such as red eyes, sore throat, mouth and tongue sores, and red or white vaginal discharge. Charred Phellodendron clears damp-heat while possessing astringent properties; it is frequently used for hematochezia and metrorrhagia.
2. Scutellaria baicalensis, Coptis chinensis, and Phellodendron amurense: All three herbs are bitter and cold in nature. They function to clear heat, dry dampness, purge fire, and resolve toxins. They are often used in combination to treat various conditions caused by damp-heat and fire-toxin, such as damp-heat diarrhea and dysentery, damp-heat jaundice, heat-toxin abscesses and swellings, redness and swelling of the eyes, blood-heat-induced vomiting of blood and epistaxis, and other fire-heat syndromes affecting various organs and viscera.The difference lies in the fact that Scutellaria baicalensis primarily enters the Lung and Large Intestine meridians, while also entering the Stomach and Gallbladder meridians, among others. Its action is focused on the Upper Jiao and the Large Intestine; it excels at clearing fire from the Lung and Large Intestine and has a significant hemostatic effect. It is particularly effective in treating warm diseases where heat has invaded the Qi,营, and Blood levels; lung heat-induced cough and wheezing; damp-heat; summer-heat dampness; damp-heat obstruction in the middle jiao; damp-heat dysuria with pain; and hemorrhoids with fistula and bloody stools;It can also clear heat and stabilize the fetus, treating fetal restlessness caused by fetal heat. Coptis (Huanglian) is extremely bitter and cold; it primarily enters the Heart and Stomach meridians, while also entering the Liver and Large Intestine meridians, among others. Its action is focused on the Heart and the middle jiao. It excels at clearing heat from the Heart and Stomach and eliminating damp-heat in the middle jiao. It is particularly effective for treating symptoms of warm diseases where heat has invaded the营 and blood levels—such as mental confusion and delirium, restlessness and insomnia,toothache caused by stomach fire, sores in the mouth and on the tongue, vomiting and acid regurgitation due to liver fire invading the stomach, fullness and distension caused by damp-heat, as well as excessive stomach fire leading to rapid digestion and constant hunger; furthermore, when used in small doses, it can strengthen the stomach, and when combined with herbs that tonify the spleen and stomach, it can treat spleen and stomach deficiency.Phellodendron (Huang Bai) is less potent than Coptis (Huang Lian). It primarily enters the Kidney and Bladder meridians, with its action focused on the Lower Jiao. It excels at clearing Kidney fire, reducing deficient heat, and eliminating damp-heat in the Lower Jiao. It is particularly effective for treating yin deficiency with excessive fire and bone-steaming tidal fever, as well as conditions caused by damp-heat in the Lower Jiao such as urinary retention, turbid dysuria, leukorrhea, genital itching, swelling and pain in the feet and knees, and beriberi.
3. Anemarrhena and Phellodendron: Both are bitter and cold in nature and capable of clearing heat, purging fire, and alleviating deficiency heat. They are often combined to treat syndromes of yin deficiency with internal heat, as in the formula Anemarrhena-Phellodendron-Rehmannia Pill (Zhibai Dihuang Wan). However, Anemarrhena is sweet, cold, and moisturizing; it is particularly effective at clearing and purging real fire in the Qi aspect of the lung and stomach, while also nourishing yin and moistening dryness. By combining clearing with tonification, it achieves an effect that addresses both the symptoms and the root cause when treating syndromes of yin deficiency with internal heat.Phellodendron (Huang Bai) is more intensely bitter and cold, primarily clearing heat and drying dampness, while also purging fire and resolving toxins; it is frequently used for conditions involving damp-heat, excess fire, and heat-toxin. When used to alleviate deficient heat, its focus is on addressing the symptoms by reducing fire, and it is often combined with herbs that tonify the kidneys and nourish yin.
Related Medicines
Bai Dai Wan, Mi Niao Ning Granules, Shi Re Bi Granules (Tablets), Ruyi Jin Huang San, and Jiu Sheng San.
Related Prescriptions
Yihuang Decoction (*Fu Qingzhu’s Gynecology*), Biqi Fenqing Decoction (*Yang’s Family Prescriptions*), Baitouweng Decoction (*Treatise on Cold Damage*), Sanmiao Pills (*Orthodox Transmission of Medicine*), Zhibai Dihuang Pills (*Examination of Medical Formulas*).
Medicinal Diet Therapy
1. Red Bean, Achyranthes, and Phellodendron Tea
(1) Effects: Clears heat, drains dampness, detoxifies, and reduces swelling. Mainly used to treat erysipelas, redness, swelling, and pain in the lower limbs caused by damp-heat descending to the lower body.
(2) Ingredients: 15 grams of adzuki beans; 10 grams each of Achyranthes root and Sichuan Phellodendron bark.
(3) Preparation: Coarsely grind the adzuki beans, Achyranthes root, and Sichuan Phellodendron bark into a coarse powder. Place the mixture in a thermos, pour in an appropriate amount of boiling water, cover, and let steep for 20 minutes before drinking while hot.
(4) Usage: Drink frequently in place of tea; one dose per day.
2. Nasal Discharge Huangbai Tea
(1) Effects: Clears heat, dries dampness, detoxifies, and unblocks the orifices. Mainly treats chronic nasal congestion, persistent purulent nasal discharge, and redness and swelling of the nasal mucosa caused by “nasal obstruction” or “nasal discharge,” which may be accompanied by chills and fever, headache, or distending pain in the brow and forehead. This corresponds to chronic rhinitis and sinusitis in modern medicine. It may also be used for suppurative otitis media.
(2) Ingredients: 15 grams of Longjing tea, 9 grams of Sichuan Phellodendron.
(3) Preparation: Grind the herbs into a fine powder, place in a thermos, pour an appropriate amount of boiling water over them, cover, and let steep for 15 minutes.
(4) Usage: Drink as a tea substitute. One dose per day; or blow the fine powder directly into both nostrils 2–3 times daily.
3. Phellodendron and Anemarrhena Wine
(1) Efficacy: Nourishes yin and reduces internal heat. Mainly treats yin deficiency with excessive internal heat, consumptive fever, and pain and weakness in the feet and knees in the elderly.
(2) Ingredients: 40 grams of Phellodendron bark, 40 grams of Anemarrhena rhizome, 40 grams of turtle shell, and 1 liter of rice wine.
(3) Preparation: Stir-fry Phellodendron bark until brown; stir-fry Anemarrhena rhizome for about 10 minutes; roast the turtle shell until crisp. Coarsely grind all three ingredients together, place them in a muslin bag, tie the opening securely, and immerse the bag in the rice wine. Seal the container. After steeping for 15 days, strain to remove the residue and retain the liquid for later use.
(4) Dosage: Take 10 milliliters once daily after lunch.
Notes
Patients requiring treatment with traditional Chinese medicine should first consult a licensed TCM hospital, where a TCM practitioner will conduct a professional diagnosis and prescribe the appropriate herbal formula.
Processing & Preparation
Harvesting & Processing
Peel the bark from April to July, scrape off the coarse outer layer, and dry it.
Processing Methods
1. Phellodendron Bark: Take the raw material, remove impurities, rinse thoroughly with water, moisten thoroughly, cut into strips, and dry.
2. Roasted Phellodendron Bark: Take clean Phellodendron strips, place them in a pan, and roast over low heat until slightly charred; remove and allow to cool.
3. Salt-Roasted Phellodendron Bark: Take clean Phellodendron strips, mix thoroughly with salt water, let stand until fully moistened, place in a pan, and roast over low heat until dry; remove and allow to cool.
4. Wine-Fried Phellodendron Bark: Take the cleaned Phellodendron Bark strips, mix thoroughly with rice wine, let them absorb the liquid completely, place them in a pan, and stir-fry over low heat until dry. Remove and let cool.
5. Charred Phellodendron Bark: Take the cleaned Phellodendron Bark strips, place them in a hot pan, and stir-fry over high heat until the surface is charred black and the interior is charred brown. Sprinkle a small amount of clean water to extinguish all embers, remove, air-dry, and let cool completely.
Storage Methods
Store in a well-ventilated, dry place to prevent moisture absorption.
Crude Drug Identification
Identification
1. The powder of this product is bright yellow. The fibers are bright yellow, 16–38 μm in diameter, often arranged in bundles; the surrounding cells contain calcium oxalate rhomboids, forming crystalline fibers; the cell walls of these crystal-containing cells are lignified and thickened. The stone cells are bright yellow, subcircular or spindle-shaped, 35–128 μm in diameter; some are branched with sharp tips at the ends, thick walls, and distinct layering;some large, fibrous stone cells are visible, reaching lengths of up to 900 μm. Numerous calcium oxalate prisms are present.
2. Take 0.2 g of the powdered sample, add 40 mL of 1% methanol-acetic acid solution, and subject to ultrasonic treatment at 60°C for 20 minutes. Filter, and concentrate the filtrate to 2 mL to prepare the test solution.Separately, take 0.1 g of Phellodendron bark reference material, add 20 mL of 1% acetic acid in methanol, and prepare a reference material solution using the same method. Then, take a reference standard of phellodendrine hydrochloride and dissolve it in methanol to prepare a solution containing 0.5 mg per mL, which serves as the reference standard solution.Test by thin-layer chromatography (General Chapter 0502): Pipette 3–5 μL of each of the three solutions and apply them separately onto the same silica gel G plate. Use the lower phase of a mixture of chloroform–methanol–water (30:15:4) as the developing solvent. Place the plate in a developing chamber saturated with ammonia vapor, allow it to develop, remove it, let it air-dry,and sprayed with a dilute potassium bismuth iodide solution. In the chromatogram of the test sample, spots of the same color appear at positions corresponding to those in the chromatograms of the reference herbal material and the reference standard.
Properties of Crude Drugs
The bark is shallowly grooved or plate-like, slightly curved, varying in length and width, and 1–6 mm thick. The outer surface is yellowish-brown or yellowish-brown, flat or with longitudinal grooves; some specimens show remnants of grayish-brown rough bark and transversely arranged lippate lenticels. The inner surface is dark yellow or pale brown, with fine, dense longitudinal ridges.It is light in weight and hard in texture; the cross-section shows a slightly granular cortex, while the phloem is fibrous, arranged in split-lamellar layers, and deep yellow in color. It has a faint odor, a very bitter taste, and a sticky texture when chewed.
Properties of Processed Slices
1. Huangbo: Slightly curled, thread-like strands; the outer surface is yellow-green or pale brownish-yellow and relatively flat; the inner surface is yellow or yellowish-brown. It is light in weight and hard in texture, with a bright yellow cross-section. It has a faint odor and a bitter taste.
2. Roasted Huangbo: Resembles Huangbo threads; the color is darker, and the texture is charred and brittle.
3. Salted Phellodendron: Resembles Phellodendron filaments; the surface is deep yellow, occasionally with scorched spots, and has a slightly salty taste.
4. Wine-processed Phellodendron: Resembles Phellodendron filaments; the surface is deep yellow, occasionally with scorched spots, and has a slight wine aroma.
5. Charred Phellodendron: Resembles Phellodendron filaments; the surface is charred black, the interior is charred brown, it is light and brittle, and has a slightly bitter and astringent taste.
Botanical Information
Botanical Classification
A plant of the genus Phellodendron in the Rutaceae family, Phellodendron amurense.
Morphological Characteristics
A tree reaching up to 15 m in height.Mature trees have a thick, longitudinally fissured cork layer, with yellow inner bark. Twigs are stout, dark purplish-red, and glabrous. The leaf rachis and petioles are stout, often densely covered with rust-brown or brown soft hairs. There are 7–15 leaflets, which are papery, oblong-lanceolate, or ovate-elliptic; the midrib of the leaf surface has short hairs, or young leaves are sparsely covered with short hairs, and the leaflet petioles are hairy.Inflorescences are terminal, with a stout inflorescence axis densely covered with short soft hairs; flowers are densely arranged. The spherical, berry-like drupes are often clustered densely together; they are blue-black and contain 5–8 locules; seeds number 5–8, rarely 10, slightly pointed at one end and bearing fine reticulate markings. Flowering occurs from May to June, and fruiting from September to November.
Distribution Area
It is distributed in Sichuan, Guizhou, Hubei, Yunnan, Shaanxi, Jiangxi, Zhejiang, and other regions.