Si Ni San，*Treatise on Cold Damage*.，For Shaoyin syndrome, where cold pathogens transform into heat and transmit to the interior, causing abdominal pain, difficulty urinating, loose stools with a sensation of heaviness in the lower abdomen, and cold extremities; as well as for disharmony between the liver and spleen, manifesting as chest and abdominal pain, loose stools with a sensation of heaviness in the lower abdomen, etc.It is currently often used for acute and chronic hepatitis, acute and chronic cholecystitis, cholelithiasis, biliary ascariasis, chronic gastritis, gastric ulcers, gastrointestinal neurosis, pancreatitis, appendicitis, intercostal neuralgia, as well as menstrual irregularities, dysmenorrhea, and pelvic inflammatory disease in women—all conditions attributed to liver qi stagnation and disharmony between the liver and spleen.
Si Ni San
Disclaimer: These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. All references in this article to TCM syndrome differentiation, herbal medicines, teas, and decoctions are intended to promote TCM culture and are provided solely for educational and reference purposes.
Formulas Name : Si Ni San
Chinese Name : 四逆散
Drug Formulation
Licorice 10 fen (roasted), Bitter Orange 10 fen (split, soaked in water, and roasted dry), Bupleurum 10 fen, Peony 10 fen.
Source
*Treatise on Cold Damage*.
Processing
Grind the ingredients into a fine powder.
Benefits
For Shaoyin syndrome, where cold pathogens transform into heat and transmit to the interior, causing abdominal pain, difficulty urinating, loose stools with a sensation of heaviness in the lower abdomen, and cold extremities; as well as for disharmony between the liver and spleen, manifesting as chest and abdominal pain, loose stools with a sensation of heaviness in the lower abdomen, etc.It is currently often used for acute and chronic hepatitis, acute and chronic cholecystitis, cholelithiasis, biliary ascariasis, chronic gastritis, gastric ulcers, gastrointestinal neurosis, pancreatitis, appendicitis, intercostal neuralgia, as well as menstrual irregularities, dysmenorrhea, and pelvic inflammatory disease in women—all conditions attributed to liver qi stagnation and disharmony between the liver and spleen.
Instructions for Use
Take one fangcun bi per dose, mixed with plain water, three times daily.
Note
This formula should not be used in cases of yin syndrome with cold extremities extending above the elbow or below the knee; it is also contraindicated for cold extremities due to cold-induced collapse, as well as for patients with liver yin deficiency or deficiency-cold of the middle qi.
Copyright: Excerpt from *Treatise on Cold Damage*., Copyright belongs to the Original Author and all original sources, This article was shared by DeDe on August 31, 2026, Please credit the source and include a link to the original article when reposting.
Terminology Proofreading: [Cheng Bo] | August 31, 2026 Reviewed by: [Wang Zhongxiang, Associate Chief TCM Physician (China)] | August 31, 2026
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Si Ni San,For Shaoyin syndrome, where cold pathogens transform into heat and transmit to the interior, causing abdominal pain, difficulty urinating, loose stools with a sensation of heaviness in the lower abdomen, and cold extremities; as well as for disharmony between the liver and spleen, manifesting as chest and abdominal pain, loose stools with a sensation of heaviness in the lower abdomen, etc.It is currently often used for acute and chronic hepatitis, acute and chronic cholecystitis, cholelithiasis, biliary ascariasis, chronic gastritis, gastric ulcers, gastrointestinal neurosis, pancreatitis, appendicitis, intercostal neuralgia, as well as menstrual irregularities, dysmenorrhea, and pelvic inflammatory disease in women—all conditions attributed to liver qi stagnation and disharmony between the liver and spleen.