Twelve-Ingredient Variant Powder，From *Chen’s Treatise on Formulas for Smallpox and Rash in Children*.，When smallpox lesions lack luster, do not swell, and the base is not red; the exterior is deficient, itchy, and sunken. When ulcers indicate yin excess and yang deficiency, accompanied by fever and thirst, cold hands and feet, a weak and feeble pulse, spontaneous loose stools, and the patient remains unaware of the heat even when drinking boiling water.
Twelve-Ingredient Variant Powder
Disclaimer: These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease. All references in this article to TCM syndrome differentiation, herbal medicines, teas, and decoctions are intended to promote TCM culture and are provided solely for educational and reference purposes.
Formulas Name : Twelve-Ingredient Variant Powder
Chinese Name : 十二味异功散
Drug Formulation
Muxiang 3 qian and a half, Cinnamomum cassia 2 qian (with coarse bark removed), Angelica sinensis 3 qian and a half, Panax ginseng 2 qian and a half, Poria 1 qian, Tangerine peel 2 qian and a half, Magnolia officinalis 2 qian and a half (processed with ginger), Atractylodes macrocephala 2 qian, Pinellia ternata (processed with ginger) 1 qian, Clove 2 qian and a half, Nutmeg 2 qian and a half, Aconite root (soaked and peeled) 1 qian and a half.
Source
From *Chen’s Treatise on Formulas for Smallpox and Rash in Children*.
Processing
Grind the ingredients into a coarse powder.
Benefits
When smallpox lesions lack luster, do not swell, and the base is not red; the exterior is deficient, itchy, and sunken. When ulcers indicate yin excess and yang deficiency, accompanied by fever and thirst, cold hands and feet, a weak and feeble pulse, spontaneous loose stools, and the patient remains unaware of the heat even when drinking boiling water.
Instructions for Use
Take 3 qian per dose. Boil with 1.5 large bowls of water, adding 5 slices of fresh ginger and 3 plump jujubes, until reduced to 6 fen. Strain and take warm on an empty stomach. For a 3-year-old child, take 3 doses; for a 5-year-old, take 2 doses; for a 2-year-old, take 3–5 doses per week.
Copyright: Excerpt from From *Chen’s Treatise on Formulas for Smallpox and Rash in Children*., Copyright belongs to the Original Author and all original sources, This article was shared by DeDe on August 31, 2026, Please credit the source and include a link to the original article when reposting.
Terminology Proofreading: [Cheng Bo] | August 31, 2026 Reviewed by: [Wang Zhongxiang, Associate Chief TCM Physician (China)] | August 31, 2026
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Twelve-Ingredient Variant Powder,When smallpox lesions lack luster, do not swell, and the base is not red; the exterior is deficient, itchy, and sunken. When ulcers indicate yin excess and yang deficiency, accompanied by fever and thirst, cold hands and feet, a weak and feeble pulse, spontaneous loose stools, and the patient remains unaware of the heat even when drinking boiling water.